CURRICULUM VITAE
Dr. Xiao-Lin Chen
Associate Professor in Plant Pathology
E-mail: chenxiaolin@mail.hzau.edu.cn
Expertise Statement
Teaching Duties
§ For undergraduate students: General Plant Pathology, Microbiology, Molecular Plant Pathology
§ For undergraduate students: Molecular Plant Pathology
§ Guide postgraduate students: Ph. D student, 4; Master degree student 6.
§ Graduated students: Master degree student, 3.
Research Interests
Mainly on molecular plant pathology, focus on Magnaporthe-rice interactions, aim to understand molecular regulatory mechanisms of the rice blast fungus infection process, which may provide novel disease control strategies such as developing novel fungicides and breeding new disease-resistant cultivar.
§ pH regulatory networks in rice blast fungus
§ Post-translational regulatory mechanisms in rice blast fungus
§ Epigenetic regulatory mechanisms in rice blast fungus
§ Molecular cell biology in rice blast fungus
§ Plant-fungus interactions (rice vs rice blast fungus)
Professional Memberships
§ Member of Chinese Society for Plant Pathology (CSPP)
Education & Working Experience
§ 2000.9-2004.7, B.S.
§ Plant Protection, Huazhong Agricultural University, Wuhan, China
§ 2004.9-2011.7, Ph.D.
§ Plant Pathology, China Agricultural University, Beijing, China
§ 2011.7-2014.10, Postdoc Research
§ State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China
§ 2014.10-2015.3, Research Assistant
§ Beijing Academy of Agricultural and forestry Sciences, Beijing, China
§ 2015.3-now, Associate Professor, doctoral supervisor
§ Collage of Plant Science & Technology, Huazhong Agricultural University, Wuhan, China
§ 2019.10-2020.8, Visiting Scientist
§ The Sainsbury Laboratory, UK
Research Support
§ Program of National Natural Science Foundation of China, "Molecular mechanisms of O-GlcNAc modification during infection of the rice blast fungus", 32072365, 2021.1-2024.12
§ Program of National Natural Science Foundation of China, "Molecular mechanisms of SUMOylation in regulation of MAPK signaling pathways in the rice blast fungus", 31871909, 2019.1-2022.12
§ Program of National Natural Science Foundation of China, “Function and mechanism of the GPI anchor modification in infection processes of the rice blast fungus”, 31601585, 2017.1-2019.12
§ Program of National Natural Science Foundation of China, “Identification of the acidic-pH signaling pathways and determine their roles during development and infection processes in the rice blast fungus”, 31571952, 2016.1-2019.12
Publications
* Corresponding author，#Co-first author
1. Cai X.#, Wang Z.#, Hou Y.X., Liu C., Hendy A., Xing J., Chen X.L.* 2020. Systematic characterization of the ubiquitin-specific proteases in Magnaporthe oryzae. Phytopathology Research, 8 (2020).
2. Cai X., Yan J., Liu C., Xing J., Ren Z., Hendy A., Zheng L., Huang J., Chen X.L.* 2020. Perilipin LDP1 coordinates lipid droplets formation and utilization for appressorium-mediated infection in Magnaporthe oryzae. Environmental Microbiology, 22(7):2843-2857. DOI: 10.1111/1462-2920.15019.
3. Chen X.L., Liu C.Y., Tang B.Z., Ren Z.Y., Wang G.L. and Liu W.D.* 2020. Quantitative proteomics analysis reveals important roles of N-glycosylation on ER quality control system for development and pathogenesis in Magnaporthe oryzae. PLOS Pathogens, 16(2): e1008355. DOI: 10.1371/journal.ppat.1008355.
4. Liu C.Y., Xing J.J., Cai X., Hendy A., He W.H., Yang J., Huang J.B., Peng Y.L., Ryder L., Chen X.L.* 2020. GPI7-mediated glycosylphosphatidylinositol (GPI) anchoring regulates appressorial penetration and immune evasion during infection of Magnaporthe oryzae. Environmental Microbiology, 22(7):2581-2595. DOI: 10.1111/1462-2920.14941.
5. Li S.J.#, Song Z.Y.#, Liu C.Y., Chen X.L.*, Han H.Y.* 2019. Biomimetic Mineralization-Based CRISPR/Cas9 ribonucleoprotein nanoparticles for gene editing. ACS Applied Materials & Interfaces. 11(51):47762-47770.
6. Wang L.Y.#, Cai X.#, Xing J.J., Liu C.Y., Hendy A., Chen X.L.* 2019. URM1-mediated ubiquitin-like modification is required for oxidative stress adaptation during infection of the rice blast fungus. Frontiers in Microbiology, 10: 2039.
7. Chen F.F., Ma R.J., Chen X.L.* 2019. Advances of metabolomics in fungal pathogen–plant interactions. Metabolites, 2019(9): 169.
8. Hendy A., Xing J.J., Chen X.Y., Chen X.L.* 2019. The farnesyltransferase β-subunit RAM1 regulates localization of RAS proteins and appressorium-mediated infection in Magnaporthe oryzae. Molecular Plant Pathology, 20(9): 1264-1278.
9. Chen X.L., Xie X., Liu C.Y., Zeng L.R., Zhou X.P., Luo F., Wang G.L.*, Liu W.D.* 2018. Proteomic analysis of ubiquitinated proteins in rice (Oryza sativa) after treatment with PAMP elicitors. Frontiers in Plant Science, (2018)9: 707.
10. Yuan J.L., Wang Z., Xing J.J., Yang Q.Y., Chen X.L.* 2018. Genome-wide Identification and characterization of circular RNAs in the rice blast fungus Magnaporthe oryzae. Scientific Reports, (2018)8: 6757.
11. Wang Z., Zhang H., Liu C.Y., Xing J.J., Chen X.L.* 2018. A deubiquitinating enzyme Ubp14 is required for development, stress response, nutrient utilization, and pathogenesis of Magnaporthe oryzae. Frontiers in Microbiology, (2018)9: 769.
12. Liu C.Y.#, Li Z.G.#, Xing J.J., Yang J., Wang Z., Zhang H., Chen D., Peng Y.L., Chen X.L.* 2018. Global analysis of sumoylation function reveals novel insights into development and appressorium-mediated infection of the rice blast fungus. New Phytologist. 219: 1031-1047.
13. Chen X.L.* 2018. Infection process observation of Magnaporthe oryzae on barley leaves. Bio-protocol, Vol 8, Iss 08. doi: 10.21769/BioProtoc.2833.
14. Li L.W.#, Chen X.L.#, Zhang S.P., Yang J., Chen D., Liu M.X., Zhang H.F., Zheng X.B., Wang P., Peng Y.L.*, Zhang Z.G.* 2017. MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzae. PLoS Genetics, 13(5): e1006814.
15. Zhou W., Shi W., Xu X.W., Li Z.G., Yin C.F., Peng J.B., Chen X.L., Zhao W.S., Zhang Y., Yang J.*, Peng Y.L. 2017. Glutamate synthase is required for conidiation, full virulence, and autophagy in the rice blast fungus, Molecular Plant Pathology, 18(2): 222-237.
16. Chen X.L.#*, Shen M.#, Yang J., Xing Y.F., Chen D., Li Z.G., Zhao W.S., Zhang Y. 2017. Peroxisomal fission is induced during appressorium formation and is required for full virulence of the rice blast fungus. Molecular Plant Pathology, 18(2):222-237.
17. Yang J., Tsiang T., Bhadauria V., Chen X.L., Li G.T. 2017. Plant Fungal Pathogenesis. Editorial. BioMed Research International, Volume 2017, doi:10.1155/2017/9724283.
18. Chen X.L.*, Wang Z., Liu C.Y. 2016. Roles of peroxisomes in the rice blast fungus. BioMed Research International, 2016:9343417.
19. Wang Y., He D., Chu Y., Zuo Y.S., Xu X.W., Chen X.L., Zhao W.S., Zhang Y., Yang J.*, Peng Y.L. 2016. MoCps1 is important for conidiation, conidial morphology and virulence in Magnaporthe oryzae. Current Genetics, 62(4): 861-871.
20. Chen X.L., Shi T., Yang J., Chen D., Xu X.W., Xu J.R., Talbot N.J., Peng Y.L* 2014. N-glycosylation of effector proteins by an alpha-1, 3-mannosyltransferase is required to evade host innate immunity by the rice blast fungus. The Plant Cell, 26: 1360-1376.
21. Li C., Yang J., Zhou W., Chen X.L., Huang J.G., Cheng Z.H., Zhao W.S., Zhang Y. Peng Y.L.* 2014. A spindle pole antigen gene MoSPA2 is important for polar cell growth of vegetative hyphae and conidia, but is dispensable for pathogenicity in Magnaporthe oryzae. Current Genetics, 60(4): 255-263.
22. Zuo Y.S., Yang J., Wang D.W., He D., Chu Y., Chen X.L., Zhou W., Hsiang T., Peng Y.L.* 2014. MoTlg2, a t-SNARE component is important for formation of the Spitzenkörper and polar deposition of chitin in Magnaporthe oryzae. Physiological and Molecular Plant Pathology, 87:9-18.
23. Du Y.X., Shi Y., Yang J., Chen X.L., Xue M.F., Zhou W.S., Peng Y.L.* 2013. A serine/threonine-protein phosphatase PP2A catalytic subunit is essential for asexual development and plant infection in Magnaporthe oryzae. Current Genetics, 59(1-2): 33-41.
24. Yang J., Kong L.A., Chen X.L., Wang D.W., Qi L.L., Zhao W.S., Zhang Y, Liu X.Z., Peng Y.L.* 2012. A carnitine-acylcarnitine carrier protein, MoCrc1, is essential for pathogenicity in Magnaporthe oryzae. Current Genetics, 58(3):139-148.
25. Chen X.L., Yang J., and Peng Y.L.* 2011. Large-scale insertional mutagenesis in Magnaporthe oryzae by Agrobacterium tumefaciens-mediated transformation. Methods in Molecular Biology, 722: 213-224.
